Comparison of efficacy of single dose versus split dose prednisolone therapy in achieving remission in patients with nephrotic syndrome in children

Background: Nephrotic syndrome is a medical problem clinically characterized by proteinuria, generalized body edema and hypercholesterolemia. We did this study to compare the effectiveness of single dose versus split prednisolone in achieving remission patients with nephrotic children.Patients methods: This open-ended randomized control trial was done pediatric unit tertiary care hospital from January December 2019.We included one hundred Patients who met inclusion criteria. divided total into 2 groups (group A & B) 50 each group. Group given prednisolone, while group B therapy. Both were compared respect achievement remission.Results: Out 37 (74%) male, 22 (44%) male (p-value=0.137). Mean age 4.5 ±1.67 years 4.9 ±1.49 respectively (p-value=0.1876). serum creatinine level 0.744±0.189 0.736±0.167 (p-value=0.823). Similarly mean albumin 2.34±0.358 2.39±0.33 (p-value=0.473). When both regard response treatment, duration 16.48 ±3.69. In 19.42 ±3.11 days (p-value<0.05).Conclusion: From our we concluded that more effective steroid sensitive as prednisolone.